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prpR prpR rpoN-2 rpoN-2 rpoN rpoN prpB prpB prpC prpC tsr-2 tsr-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
prpRPutative sigma interaction-related Fis-family transcriptional regulator; Similar to Burkholderia sacchari PrpR SWALL:Q8VPT1 (EMBL:AY033092) (646 aa) fasta scores: E(): 3.9e-121, 60.78% id in 663 aa, and to Escherichia coli propionate catabolism operon regulatory protein PrpR or b0330 SWALL:PRPR_ECOLI (SWALL:P77743) (528 aa) fasta scores: E(): 3e-41, 36.99% id in 673 aa. CDS is extended at the C-terminus in comparison to orthologues. (694 aa)    
Predicted Functional Partners:
rpoN-2
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.798
rpoN
Putative RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.796
prpB
Probable methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
     
 0.573
prpC
Similar to Escherichia coli 2-methylcitrate synthase PrpC or b0333 SWALL:PRPC_ECOLI (SWALL:P31660) (389 aa) fasta scores: E(): 3.5e-119, 78.61% id in 374 aa, and to Burkholderia sacchari 2-methylcitrate synthase PrpC SWALL:Q8VPS9 (EMBL:AY033092) (388 aa) fasta scores: E(): 1.2e-133, 86.15% id in 390 aa.
     
 0.415
tsr-2
Similar to Escherichia coli methyl-accepting chemotaxis protein I Tsr or CheD or b4355 SWALL:MCP1_ECOLI (SWALL:P02942) (551 aa) fasta scores: E(): 7.7e-55, 47.52% id in 484 aa, and to Ralstonia solanacearum probable methyl-accepting chemotaxis transmembrane protein rsc1234 or rs02741 SWALL:Q8Y011 (EMBL:AL646063) (514 aa) fasta scores: E(): 1.4e-100, 65.1% id in 513 aa.
     
 0.400
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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